• This section is intended for qualified medical personnel only. If you are not a healthcare professional, please consult your physician

  • این بخش صرفاً ویژه متخصصان حوزه سلامت است. در صورت نداشتن صلاحیت پزشکی، با پزشک خود مشورت نمایید

MECHANISM OF ACTION

?What the Hypochlorous

It was first described by Sir Davy in 1823, produced by Faraday in 1881, and used as an antiseptic solution during World War I in 1914.

This physiological molecule is synthesized during the phagocytosis action of neutrophils, which play an important role in the defense mechanisms of living organisms. Activation of neutrophils produces reactive oxygen species (ROS). Hydrogen peroxide (H₂O₂) and the enzyme myeloperoxidase are involved in the process to produce hypochlorous in the presence of H₂O₂, Cl⁻, and H⁺.

■ 200 ppm ■ ORP ±900 mv ■ pH ≈7.1

DNA DAMAGE

Fracture in DNA
Suppression of DNA synthesis

ENERGY PRODUCTION EFFECTS

Oxidation of respiratory components (ROS)
Reduction in adenosine triphosphate production

EFFECTS ON CELLULAR ENVIRONMENT

Intercellular material loss
Reduction in food intake
Reduction of oxygen uptake

PROTEIN SYNTHESIS INHIBITION

Oxidation of sulfhydryl enzymes
Oxidation of amino acids
Chlorination of amino acids
Inhibition of protein synthesis

In this study, Pseudomonas aeruginosa cells were stained with fluorescence and subjected to hypochlorous under a video microscope to determine how quickly they were killed. With its high redox potential (ORP), it removes electrons from the atoms of microorganisms and acts on all vital parts, from the cell wall structure to DNA, killing them within seconds.

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ANTIMICROBIAL ACTION AGAINST BIOFILMS

It eradicates the biofilm layer formed by resistant microorganisms. It also kills microorganisms in dormant form under the biofilm.

EFFECTS OF HEALING PROCESS ACCELERATOR

According to the clinical study performed with povidone-iodine on fibroblasts and keratinocytes:

In addition to its antimicrobial activity, it shortens the healing process by accelerating the migration of fibroblasts and keratinocytes to the wound site — the two main cells responsible for tissue repair.

Effect on Fibroblasts

Effect on Keratinocyte

INDICATIONS

In all the following applications, when used as an adjunct to existing antibiotherapy, it reduces the dosage and duration of antibiotic use and accelerates recovery.

NON-WOUND APPLICATIONS

  • In the treatment of oral aphthae caused by viruses or fungi

  • Effective in the prevention and treatment of herpes simplex virus infections

  • Treatment of bacterial and viral eye infections

  • Eye and surrounding area care

  • Ear and periauricular care

  • Facial cleansing for acne and pimples

WOUND CARE APPLICATIONS

  • Treatment of diabetic foot wounds

  • Pressure ulcers in back, hip, heel, etc., developed over long periods

  • Treatment of acute and chronic wounds, regardless of cause

  • Treatment of partial and full-thickness skin injuries

  • Postoperative wound care

  • Care of graft mesh, punch skin grafts, and biopsies

  • Treatment of burns (1st to 2nd degree)

  • Skin ulcers (Stage I–IV)

  • Prevention and treatment of skin damage due to trauma, scratches, or cuts

  • Treatment of abscesses

  • Wound irrigation and debridement (removal of necrotic tissue)

  • Moisturizing the wound and reducing odor

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REFERENCES