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.THIS SECTION IS INTENDED FOR EXPERT MEDICAL STAFF. CONSULT YOUR DOCTOR IF YOU ARE NOT A SPECIALIZED MEDICAL STAFF
ANTIMICROBIAL EVENTS
?What the Hypochlorous
It was first described by Sir Davy in 1823, produced by Faraday in 1881 and used as antiseptic solution during World War I in 1914.
This physiological molecule is synthesized during the phagocytosis action of neutrophils, which play an important role in the defense mechanisms of living things. Activation of neutrophils produces reactive oxygen species [ROS] Hydrogen peroxide [HO] and myeloperoxidase enzyme is involved in the process to produce HYPOCHLOROUS in the presence of H2O2 Cl and H+.
■ 200 ppm ■ ORP ±900 mv ■ pH ≈7.1
DNA DAMAGE
Suppression of DNA synthesis
ENERGY PRODUCTION
Reduction in adenosine triphosphate production
ENVIRONMENTAL RELATIONSHIP
Reduction in food intake
Reduction of oxygen uptake
PROTEIN SYNTHESIS
Oxidation of amino acids
Chlorination of amino acids
Inhibition of protein synthesis
In this study, Pseudomonas Aeruginosa cells were stained with fluorescence and subjected to hypochlorous under video microscope and it was determined how long it was killed. With its High Redox Potential (ORP), it removes electrons from atoms of microorganisms and acts on all vital parts of the cell wall structure and DNA, killing them in seconds.
- *Corynebacterium amycolatum
- *Enterobacter aerogenes
- Actynomcesler
- Chlamidialar
- Bacteriodesler
- **Acinetobacter baumanii
- Bordetella bronchiseptica
- Citrobacter freundii
- Corynebacterium kutscheri
- *Enterecoccus feecium
- *Escherichia coli
- *influenzae
- Haemophilus
- Klebsiella
- *pneumoniae
- *Micrococcus luteus
- Mycobacteriumlar
- Enterobacter cloacae
- *Enterococcus faecalis
- **Klebsiella oxytoca
- Listonella anguillarum
- Moraxella catarrhalis
- *Proteus mirabilis
- Pseudomonas
- *aeruginosa
- *Serratia marcences
- Mycoplasmalar
- Rhizobialar
- Pasteurella
- pneumotropica
- Salmonella enteritidis
- Salmonella paratyphi A
- Salmonella typhi
- Shigella flexneri
- Bacilluslar (sporlu ve sporsuz formlara)
- Clostridiumlar (sporlu ve sporsuz)
- Chryseobacterium
- Meningosepticum
- *Staphylococcus aureus
- Staphylococcus
- *epidermidis
- Staphylococcus
- *haemolyticus
- *Staphylococcus hominis
- Staphylococcus
- *saprophyticus
- Stenotrophomonas
- maltophilia
- Streptococcus
- pneumoniae
- Streptococcus pyogenes
- Adenoviridealar: Adenovirus
- Picarnoviridae: Coxakivirus
- Herpersviridae: Ebstein-barr virus,
- Herpes simplex tip 1, 2 ve 8
- Cytomegalovirus, Varicella Zoster
- Hepadnaviridae: Hepatitis B virus
- Flaviviridae: Hepatitis C virus
- Retroviridae: HIV
- Orthomyxoviridae: Influenza virus
- Paramyxoviridae: Mumps, Measles
- Respiratory Syncitial virus (Hrsv)
- Papoviridea: Papillomavirus
- Rhabdoviridea: Rotovirus
- Togoviridae: Rubella Virus
- Poliovirus
- Parainfluenza
- Parainfluenza
- Hepatitis A virus
- Aspergillus fumigatus
- Aspergillus niger
- Candida Albicans
- Microsporum
- Epidermophyton floccosum*
- Rhizopus oryzae
- Trichophyton rubrum*
- Trichopyton tonsurans*
- Trichophyton verrucosum*
BIOFILMS ACTIVITY
It eradicates the biofilm layer formed by resistant microorganisms. It also kills microorganisms in dormant form under the biofilm.
EFFECTS OF PROCESS IMPROVEMENT ACCELERATOR
According to the clinical study performed with Povidone iodine on fibroblasts and keratinocytes;
In addition to antimicrobial activity, it shortens the healing process by accelerating the migration of Fibroblast and Keratinocytes to the wound site, which are the two main cells responsible for tissue healing.
Effect on Fibroblasts
Effect on Keratinocyte
INDICATIONS
In all the following applications, when used as an adjunct to existing antibiotherapy, antibiotherapy reduces the amount and duration of use. Accelerates recovery.
NON-WOUND APPLICATIONS
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In the treatment of oral aphthae with virus or fungi
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Herpes Simplex virus is effective in the prevention and treatment of herpes problems
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Treatment of bacterial and viral eye infections
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Eye and environment care
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Care of the ear and its surroundings
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Facial cleansing against acne and pimplesFacial cleansing against acne and pimples
WOUND CARE APPLICATIONS
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Treatment of diabetic foot wounds
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Back, hip, heel and so on developed for a long time
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Whatever the cause, treatment of acute and chronic wounds
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In the treatment of partial and complete skin injuries
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In the treatment of postoperative wounds
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Graft mesh, punch skin grafts and biopsies
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Treatment of burns (1 degree to 2 degree)
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Skin Ulcers (Stage I-IV)
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Prevention and treatment of skin problems caused by bumps, scratches and cuts
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In the treatment of abscesses
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Wound irrigation and debridement (removal of dead tissues)
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Moistening the wound and reducing its odors
REFERENCES
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The inhibition of bacterial growth by hypochlorous acid.Possible role in the bactericidal activity of phagocytes - McKenna 1988
Susan M. McKENNA and Kelvin J. A. DAVIES
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Hypochlorous Acid - Analytical Methods and Antimicrobial Activity-2012-Ankara Üniversity
Müjde Eryılmaz and İsmail Murat Palabıyık
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Hypochlorous Acid as a Potential Wound Care Agent – 2007
Wang L, PhD,a Bassiri M, PhD,a Najafi R, PhD,a Najafi K, MD,b Yang J, BS,a Khosrovi B, PhD,a Hwong W, BS,a Barati E, BS,a Belisle B, PhD,a Celeri C, MSa,and Robson MC, MDc
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Hypochlorous acid is antipruritic and anti-inflammatory in a mouse model of atopic dermatitis -Fukuyama- 2017
T. Fukuyama, B. C. Martel, K. E. Linder, S. Ehling, J. R. Ganchingco, W. Baumer
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Fungal Infections Following Boston Type 1 Keratoprosthesis Implantation Literature Review and In Vitro Antifungal Activity of Hypochlorous-2015
Silvia Odorcic, MD, FRCSC, Wolfgang Haas, PhD, Michael S. Gilmore, PhD, and Claes H. Dohlman, MD, PhD
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Hypochlorous-Acid-Generating Electrochemical Scaffold for Treatment of Wound Biofilms-2019
Mia Mae Kiamco, Hannah M. Zmuda, Abdelrhman Mohamed, Douglas R. Call, Yash S . Raval, Robin Patel & Haluk Beyenal
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I-İslam I.Ragap -The Effectiveness of Hypochlorous Acid Solution on Healing of Infected Diabetic Foot Ulcers
Islam.I.Ragab1 Ahmed Kamal 2
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Hypoclorous acid Demonstrates Antiviral Properties Against Herpes Simplex Virus - 2010
G.A. Denys, V. Dzyakanava, P. O’Hanley, and J.T. Stephens, Jr.
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Stabilised Hypoclorous acid A New Therapeutic Strategy Against Dangerous Parasitic Eye Infection Agent - Acanthamoeba spp.- 2018
I. YILDIZ, O. YILMAZ, E. TILEKLIOGLU, S. SAKARYA, H. ERTABAKLAR
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Improved Outcomes After Low-Concentration Hypochlorous Acid-The Laryngoscop-2015
Hyung-Ju Cho, MD, PhD; Hyun Jin Min, MD, PhD; Hyo Jin Chung, MD; Do-Yang Park, MD; Sang Yeob Seong, MD; Joo-Heon Yoon, MD, PhD; Jeung-Gweon Lee, MD, PhD; Chang-Hoon Kim, MD, PhD
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The Role of Hypochlorous Acid in Managing Wounds
Martha Kelso
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In vitro microbicidal, anti-biofilm and cytotoxic effects of different commercial antiseptics-2017
Silvestre Ortega-Peña, Christian Hidalgo-González, Martin C Robson & Edgar Krötzsch
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Clinical Outcomes of Wide Postsurgical Lesions in the Infected Diabetic Foot Managed With 2 Different Local Treatment Regimes Compared Using a Quasi-Experimental Study Design: A Preliminary Communication
Chiara Goretti, Sabrina Mazzurco, Laura Ambrosini Nobili, Silvia Macchiarini, Anna Tedeschi, Francesca Palumbo, Alessia Scatena, Loredana Rizzo, Alberto Piaggesi
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Inactivation of bacteria on surfaces by sprayed slightly acidic hypochlorous acid-Hakimullah Hakim-2016
Hakimullah HAKIM), Md. Shahin ALAM), Natthanan SANGSRIRATANAKUL), Katsuhiro NAKAJIMA), Minori KITAZAWA), Mari OTA), Chiharu TOYOFUKU), Masashi YAMADA), Chanathip thammakarn), Dany SHOHAM) and Kazuaki TAKEHARA
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Hypochlorous Acid Solution: A Tale Of Two Clinics A Safe Effective Alternative for Treating and Preventing Infection?
Kazu Suzuki DPM, CWS, Albemar Espirtu DPM, WCC
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Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid - 2016-Canada
Andrew G. Hughson, Brent Race, Allison Kraus, Laura R. Sangare, Lori Robins, Bradley R. Groveman, Eri Saijo, Katie Phillips, Luis Contreras, Virkamal Dhaliwal, Matteo Manca, Gianluigi Zanusso, Daniel Terry, Jeffrey F. Williams, Byron Caughey
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Hypochlorous Acid An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm and Wound Healing Potency - 2014
Serhan Sakarya, MD1; Necati Gunay, MS2; Meltem, Karakulak, MS3; Barcin Ozturk, MD1; Bulent Ertugrul, MD1
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International Wound Infection Institute (IWII) Wound infection in clinical practice. Wounds - International 2016 UPDATE
Terry Swanson
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Adjunctive Debridement with Hypoclorous acid Leads To A Healing Trajectory Of Complex Wounds In Children-2016
Ferne T. Elsass, MSN, RN, CPN, CWON; Clinical Practice and Education Specialist of Wound and Ostomy, Children’s Hospital of The King’s Daughters, Norfolk, VA 23507
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IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes 2016 -Lipsky
Benjamin A. Lipsky, Javier Aragón-Sánchez, Mathew Diggle, John Embil, Shigeo Kono, Lawrence Lavery, Éric Senneville, Vilma Urbančič-Rovan, Suzanne Van Asten, Edgar J. G. Peters
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Antimicrobial effect of hypochlorous acid on pathogenic microorganisms-2013-Korea
Sang Phil Shin1,*, Mun Sup Kim1,*, Sung Hee Cho2, Ji Hyung Kim1, Casiano H. Choresca Jr1, Jee Eun Han1, Jin Woo Jun1, Se Chang Park1,†
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Low-concentration hypochlorous acid nasal irrigation for chronic sinonasal symptoms a prospective randomized placebo-controlled study-2017
Yu MS, Kim BH, Kang SH, Lim DJ
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Antiseptik bazlı çözeltilerin İnsan Keratinosit Hücre Dizisi(Hacat) Proliferasyonuna etkilerinin karşılaştırılması - 2013
Arzu Onay Beşikçi, Tuğbay Tuğ
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Topical Hypochlorous Acid (HOCl) as a Potential Treatment of Pruritus 2013
Robert Y. Pelgrift
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Disinfection of titanium dioxide nanotubes using super-oxidized water decrease bacterial viability without disrupting osteoblast behavior-2016
Ernesto Beltrán-Partida a,b, Benjamín Valdez-Salas b,⁎, Alan Escamilla b, Mario Curiel b, Ernesto Valdez-Salas c, Nicola Nedev b, JoseM. Bastidas
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Universal decolonization with hypochlorous solution in a burn intensive care unit in a tertiary care community hospital 2016
Gray D, Foster K, Cruz A, Kane G, Toomey M, Bay C, Kardos P, Ostovar GA
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Use of Hypochlorous Acid Solution as a Disinfectant in Laboratory Animal Facilities-2015
Kazuo Goto, Kaga, Itabashi-ku
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Effect of Electrolyzed Strong Acid Water on Peritoneal Irrigation of Experimental Perforated Peritonitis-2009 - Japan
Akio Kubota, Keisuke Nose, Takeo Yonekura, Takuya Kosumi, Katsuji Yamauchi and Harumasa Oyanagi
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Hypoclorous acid Irrigation in Reducing Infection of a Median Sternotomy Wound-2010
Abdul Ramzisham Rahman Mohd, MS, Mohd Khairulasri Ghani, MD, Rafl is Ruzairee Awang, MBChB, Joanna Ooi Su Min, MMed, Mohd Zamrin Dimon, MS
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Expert Recommendations For The Use Of Hypoclorous Solution Science and clinical application - 2015
David G. Armstrong, DPM, MD, PhD, Gregory Bohn, MD, FACS, ABPM/UHM, FACHM, Paul Glat, MD, FACS, Steven J. Kavros, DPM, FACCWS,CWS, Robert Kirsner, MD, PhD, Robert Snyder, DPM, MSc, CWS, William Tettelbach, MD, FACP, CWS
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Effects of Hypochlorous Acid Solutions on Venous Leg Ulcers (VLU) Experience With 1249 VLUs in 897 Patients -2016
Cheryl M. Bongiovanni, PhD, RVT, CWS, FASA, FACCWS